Evaluation of TLR-2 sera levels in a sample of Iraqi pulmonary TB patients

  • Lara Ghali A. Ali Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq
  • Nawal Mohammed Utba Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq
  • Ahmed Asmer Mankhi National Reference Laboratory of TB, Ministry of Health, Baghdad, Iraq

Abstract

The non-specific response of immunity has developed as the initial barrier for human protection from invading pathogens, which comprises certain pathogen recognition receptors (PRR) for instance toll-like receptors (TLRs). Toll like receptor 2 (TLR 2) is capable of recognizing pathogen associated molecular patterns (PAMP) coded by Mycobacterium tuberculosis. To evaluate TLR 2 level in sera of pulmonary tuberculosis (TB) patients. About 120 subjects, involving 80 patients with pulmonary TB including 40 multiple drug resistance (MDR), 20 recently diagnosed pulmonary TB (RD) and 20 recurrent TB patients named as old cases (OC), in addition to 40 apparently healthy individuals were studied as control group. Sera from 68 TB patients and 20 healthy controls were obtained for measuring TLR 2 levels by enzyme linked immunosorbent assay (ELISA). The present result revealed that serum levels of TLR 2  showed there is no significant differences between each patient's group and control except OC group given that, has decreased significantly (p<0.05). The mean ±SD  of TLR 2 level in MDR, RD, OC and controls were 4.0± 2.4, 3.4±1.4, 2.2±0.9 and 4.1± 3.0 ng/ml, respectively. The results exhibited that during treatment of tuberculosis, patients with pulmonary tuberculosis showed elevated TLR 2 concentration, which looks probably in charge of regulating inflammation and infection. Consequently, this study proposes that killing of MTB could occur in the time of disease management because of effective treatment, in addition to activation and releasing of different immune system mediators via TLR 2.

Published
Nov 28, 2018
How to Cite
ALI, Lara Ghali A.; UTBA, Nawal Mohammed; MANKHI, Ahmed Asmer. Evaluation of TLR-2 sera levels in a sample of Iraqi pulmonary TB patients. Iraqi Journal of Science, [S.l.], p. 1973-1980, nov. 2018. ISSN 2312-1637. Available at: <http://scbaghdad.edu.iq/eijs/index.php/eijs/article/view/530>. Date accessed: 11 dec. 2018.
Section
Biology